Lefèvre Thierry, Sanchez Marta, Ponton Fleur, Hughes D., Thomas F. (2007). Virulence and resistance in malaria : who drives the outcome of the infection?. Trends in Parasitology, 23 (7), p. 299-302. ISSN 1471-4922.
Titre du document
Virulence and resistance in malaria : who drives the outcome of the infection?
Lefèvre Thierry, Sanchez Marta, Ponton Fleur, Hughes D., Thomas F.
Source
Trends in Parasitology, 2007,
23 (7), p. 299-302 ISSN 1471-4922
Theoretical and experimental studies have established the dynamic nature of virulence and that, like all traits, it has evolved. Understanding parasite evolution offers a conceptual framework for diverse fields and can contribute greatly to decision-making in disease control. Recently, Grech et al. investigated the effects of host genotype-by-parasite genotype interactions on the expression of virulence in an artificial rodent-malaria system. They found that both parasite and host effects explained most of the variance in the virulence, resistance and transmission potential. These findings are a major contribution to the emerging debate on the pros and cons of a coevolutionary approach of virulence evolution; they also hold great potential for more effective control strategies.
