Massiot G., Long C., David B., Serrano M. J., Daubie F., Alby F., Ausseil F., Knibiehler M., Moretti C., Hoffmann J. S., Cazaux C., Lavaud C. (2005). Acylphloroglucinol derivatives from Mahurea palustris. Journal of Natural Products, 68 (7), p. 979-984. ISSN 0163-3864.
Titre du document
Acylphloroglucinol derivatives from Mahurea palustris
Massiot G., Long C., David B., Serrano M. J., Daubie F., Alby F., Ausseil F., Knibiehler M., Moretti C., Hoffmann J. S., Cazaux C., Lavaud C.
Source
Journal of Natural Products, 2005,
68 (7), p. 979-984 ISSN 0163-3864
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 mu M range.
